Keloid treatment strategies include steroid injections, radiotherapy, cryotherapy and excisional surgery, but they do not provide satisfactory outcomes. Keloid scars (KS) are cosmetically frustrating problems frequently associated with functional deformities. Keloid is a poorly regressing cutaneous lesion characterised by haphazard dermal fibrosis and excessive skin growth beyond original wound boundaries, which reflects pathological wound healing. does not alter our adherence to PLOS ONE policies on sharing data and materials. The specific roles of these authors are articulated in the ‘author contributions’ section.Ĭompeting interests: ICO co. 2012M3A9B2052870) to CHK, and the Basic Science Research Program through the National Research Foundation of Korea (NRF) (grant no. 2015R1A2A1A01002968) to CHK, the Bio & Medical Technology Development Program (grant no. This study was also supported by the National Research Foundation of Korea (grant no. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: The funder (ICO co.) provided support in the form of salaries for authors JBR and YL, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Received: ApAccepted: OctoPublished: November 16, 2017Ĭopyright: © 2017 Kang et al. PLoS ONE 12(11):Įditor: Mohammed Yousfi, Universite Toulouse III Paul Sabatier, FRANCE (2017) Opposite effects of non-thermal plasma on cell migration and collagen production in keloid and normal fibroblasts. Our data suggest that NTP may be a new therapeutic strategy for keloids.Ĭitation: Kang SU, Kim YS, Kim YE, Park J-K, Lee YS, Kang HY, et al. We revealed that NTP suppressed KF cell migration via down-regulation of EGFR and STAT3 and reduced collagen production via supressing transforming growth factor-β. NTP reduced the expression of EGFR, STAT3, and Type I collagen in KFs but increased their levels in NFs. However, it reduced these parameters in KFs. ![]() NTP treatment increased cell migration and collagen production of NFs. Expression of the transforming growth factor-β and Type I collagen following NTP treatment was determined by reverse transcription-polymerase chain reaction, immunofluorescence staining, and the Sircol collagen assay. We assessed NTP effects on cell migration in KFs and NFs by the wound healing assay and measured the expression of the epidermal growth factor receptor (EGFR), signal transducer and activator of transcription-3 (STAT3), and collagen by western blot. ![]() We sought to investigate the effect of NTP treatment on keloid by comparing cell migration and collagen production of keloid (KFs) and normal fibroblasts (NFs) and determined the regulatory pathways involved. However, therapeutic effect of NTP on keloid cells has not been reported previously. Recent progress in the understanding non-thermal plasma (NTP) properties prompted its application in the treatment of various diseases.
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